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Journal Articles mBio Year : 2022

Active Surveillance Program to Increase Awareness on Invasive Fungal Diseases: the French RESSIF Network (2012 to 2018)

Stéphane Bretagne (1, 2, 3) , Karine Sitbon (1, 3) , Marie Desnos-Ollivier (1, 3) , Dea Garcia-Hermoso (1, 3) , Valérie Letscher-Bru (4) , Sophie Cassaing (5, 6) , Laurence Millon (7) , Florent Morio (8) , Jean-Pierre Gangneux (9) , Lilia Hasseine (10) , Loïc Favennec (11) , Estelle Cateau (12, 13) , Eric Bailly (14) , Maxime Moniot (15) , Julie Bonhomme (16) , Nicole Desbois-Nogard (17) , Taieb Chouaki (18) , André Paugam (19) , Bernard Bouteille (20) , Marc Pihet (21, 22, 23) , Frédéric Dalle (24) , Odile Eloy (25) , Milène Sasso (26) , Magalie Demar (27) , Patricia Mariani-Kurkdjian (28) , Vincent Robert (29) , Olivier Lortholary (1, 3, 30) , Françoise Dromer (1, 3) , The French Mycoses Study Group , Céline Damiani (31) , Hervé Dupont (32) , Julien Maizel (33) , Anne Totet (31) , Jean-Philippe Bouchara (23, 21, 34) , Anne Pauline Bellanger , Ana Berceanu , Jean Christophe Navellou , Emeline Scherer , Philippe Abboud , Christine Aznar , Denis Blanchet , Félix Djossou , Sophie Cayot , Cyril Garrouste , Olivier Lesens , Cécile Moluçon , Céline Nourrisson , Philippe Poirier , Éloïse Bailly , Louise Basmaciyan , Bouhemad Belaid , Mathieu Blot , Denis Caillot , Pierre-Emmanuel Charles , Jean Pierre Quenot , Emmanuelle Amazan , Emilie Baubion , André Cabie , Cyrille Chabartier , Christophe Deligny , Violaine Emal , Olivier Flechelle , Yves Hatchuel , Yohann Le Govic (31) , Harold Merle , Charline Miossec , Jean-Marie Turmel , Ruddy Valentino , Marie-Fleur Durieux , Pascal Turlure , Victor Mercier , Martine Gari-Toussaint , Karine Risso , Loïc Simon , Cedric Bretonnière , David Boutoille , Thomas Gastinne , Karim Lakhal , Elise Launay , Thierry Lepoivre , Pierre Peterlin , Fanny Rialland , Patrice Le Pape , Etienne Canoui , Naima Dahane , Solène Kerneis , Cécile Angebault , Marie-Elisabethh Bougnoux , Nadia Guennouni , Fanny Lanternier , Bennedicte Neven , Mehdi Oualha , Anne Scemla , Emilie Sitterlé , Felipe Suarez , Julie Toubiana , Stéphane Bonacorci , Alexandre Alanio , Anne Bergeron , Blandine Denis , Maud Gits-Muselli , Samia Hamane , Sophie Touratier , Christine Chaumeil , Lilia Merabet , Joelle Claudéon , Elodie Curlier , Valérie Galantine , Jean Claude Gallois , Samuel Markowicz , Muriel Nicolas , Pascal Musson , Kinda Schepers , Alida Minoza , Catherine Kauffmann-Lacroix , Hélène Guégan , Damien Costa , Marion Dehais , Gilles Gargala , Odile Bajolet , Firouze Banisadr , Joel Cousson , Chantal Himberlin , Antoine Huguenin , Dominique Toubas , Pierre Flori , Caroline Mahinc , Hélène Raberin , Julie Denis , Raoul Herbrecht , Paul-Michel Mertes , Fehrat Meziani , Marcela Sabou , Francis Schneider , Anne-Isabelle Bertozzi , Pamela Chauvin , Elena Charpentier , Olivier Cointault , Claire Cottrel , Karen Delavigne , Stanislas Faguer , Judith Fillaux , Emilie Guemas , Xavier Iriart , Lucie Lelièvre , Jean Ruiz , Frédéric Bastides , Adélaïde Chesnay , Guillaume Desoubeaux (35, 36) , Audrey Therby , Elisabeth Chachaty , Bertrand Gachot
1 Mycologie moléculaire - Molecular Mycology
2 AP-HP - Hopital Saint-Louis [AP-HP]
3 CNRMA - Centre National de Référence Mycoses Invasives et Antifongiques - National Reference Center Invasive Mycoses & Antifungals
4 DIHP - Dynamique des interactions hôte pathogène
5 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
6 RESTORE - Geroscience and rejuvenation research center
7 LCE - Laboratoire Chrono-environnement (UMR 6249)
8 Nantes Univ - Nantes Université
9 Irset - Institut de recherche en santé, environnement et travail
10 CHU Nice - Centre Hospitalier Universitaire de Nice
11 CHU Rouen
12 CHU de Poitiers - Centre hospitalier universitaire de Poitiers = Poitiers University Hospital
13 EBI [Poitiers] - Écologie et biologie des interactions
14 CHRU Tours - Centre Hospitalier Régional Universitaire de Tours
15 CHU Clermont-Ferrand
16 CHU Caen
17 CHU de la Martinique [Fort de France]
18 CHU Amiens-Picardie
19 Hôpital Cochin [AP-HP]
20 CHU Limoges
21 ICAT - SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques
22 Laboratoire de Parasitologie-Mycologie (CHU d'Angers)
23 IRF - Infections Respiratoires Fongiques
24 PAM - Procédés Alimentaires et Microbiologiques [Dijon]
25 CHV - Centre Hospitalier de Versailles André Mignot
26 MIVEGEC - Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle
27 Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]
28 Hôpital Robert Debré Paris
29 WI - Westerdijk Fungal Biodiversity Institute [Utrecht]
30 Service des Maladies infectieuses et tropicales [CHU Necker]
31 AGIR - Agents infectieux, résistance et chimiothérapie - UR UPJV 4294
32 SSPC - Simplification des soins chez les patients complexes - UR UPJV 7518
33 MP3CV - Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517
34 Laboratoire de Parasitologie-Mycologie [CHU Angers]
35 Hôpital Bretonneau
36 CEPR - Centre d’Etude des Pathologies Respiratoires (CEPR), UMR 1100
Florent Morio
Loïc Favennec
  • Function : Author
Julie Bonhomme
  • Function : Author
Bernard Bouteille
  • Function : Author
The French Mycoses Study Group
  • Function : Author
  • PersonId : 1035501
Anne Pauline Bellanger
  • Function : Author
Ana Berceanu
  • Function : Author
Jean Christophe Navellou
  • Function : Author
Emeline Scherer
  • Function : Author
Philippe Abboud
  • Function : Author
Christine Aznar
  • Function : Author
Denis Blanchet
Félix Djossou
Sophie Cayot
  • Function : Author
Cyril Garrouste
Olivier Lesens
  • Function : Author
Cécile Moluçon
  • Function : Author
Céline Nourrisson
Philippe Poirier
Éloïse Bailly
  • Function : Author
Louise Basmaciyan
Bouhemad Belaid
  • Function : Author
Mathieu Blot
  • Function : Author
Denis Caillot
  • Function : Author
Pierre-Emmanuel Charles
  • Function : Author
Jean Pierre Quenot
Emmanuelle Amazan
  • Function : Author
Emilie Baubion
  • Function : Author
André Cabie
  • Function : Author
Cyrille Chabartier
  • Function : Author
Christophe Deligny
  • Function : Author
Violaine Emal
  • Function : Author
Olivier Flechelle
  • Function : Author
Yves Hatchuel
  • Function : Author
Harold Merle
  • Function : Author
Charline Miossec
  • Function : Author
Jean-Marie Turmel
  • Function : Author
Ruddy Valentino
  • Function : Author
Marie-Fleur Durieux
  • Function : Author
Pascal Turlure
  • Function : Author
Victor Mercier
  • Function : Author
Martine Gari-Toussaint
  • Function : Author
Karine Risso
  • Function : Author
Loïc Simon
  • Function : Author
Cedric Bretonnière
  • Function : Author
David Boutoille
Thomas Gastinne
  • Function : Author
Karim Lakhal
  • Function : Author
Elise Launay
Thierry Lepoivre
  • Function : Author
Pierre Peterlin
Fanny Rialland
  • Function : Author
Patrice Le Pape
  • Function : Author
Etienne Canoui
  • Function : Author
Naima Dahane
  • Function : Author
Solène Kerneis
  • Function : Author
Cécile Angebault
Marie-Elisabethh Bougnoux
  • Function : Author
Nadia Guennouni
  • Function : Author
Fanny Lanternier
  • Function : Author
Bennedicte Neven
  • Function : Author
Mehdi Oualha
  • Function : Author
Anne Scemla
  • Function : Author
Emilie Sitterlé
  • Function : Author
Felipe Suarez
Julie Toubiana
Stéphane Bonacorci
  • Function : Author
Alexandre Alanio
  • Function : Author
Anne Bergeron
  • Function : Author
Blandine Denis
  • Function : Author
Maud Gits-Muselli
  • Function : Author
Samia Hamane
  • Function : Author
Sophie Touratier
  • Function : Author
Christine Chaumeil
  • Function : Author
Lilia Merabet
  • Function : Author
Joelle Claudéon
  • Function : Author
Elodie Curlier
  • Function : Author
Valérie Galantine
  • Function : Author
Jean Claude Gallois
  • Function : Author
Samuel Markowicz
  • Function : Author
Muriel Nicolas
  • Function : Author
Pascal Musson
  • Function : Author
Kinda Schepers
  • Function : Author
Alida Minoza
  • Function : Author
Catherine Kauffmann-Lacroix
  • Function : Author
Hélène Guégan
  • Function : Author
Damien Costa
Marion Dehais
  • Function : Author
Gilles Gargala
  • Function : Author
Odile Bajolet
  • Function : Author
Firouze Banisadr
  • Function : Author
Joel Cousson
  • Function : Author
Chantal Himberlin
  • Function : Author
Antoine Huguenin
  • Function : Author
Dominique Toubas
  • Function : Author
Pierre Flori
  • Function : Author
Caroline Mahinc
  • Function : Author
Hélène Raberin
  • Function : Author
Julie Denis
  • Function : Author
Raoul Herbrecht
Paul-Michel Mertes
Fehrat Meziani
  • Function : Author
Marcela Sabou
  • Function : Author
Francis Schneider
Anne-Isabelle Bertozzi
  • Function : Author
Pamela Chauvin
  • Function : Author
Elena Charpentier
  • Function : Author
  • PersonId : 1165717
Olivier Cointault
  • Function : Author
Claire Cottrel
  • Function : Author
Karen Delavigne
  • Function : Author
Stanislas Faguer
Judith Fillaux
  • Function : Author
Emilie Guemas
  • Function : Author
Xavier Iriart
Lucie Lelièvre
  • Function : Author
Jean Ruiz
  • Function : Author
Frédéric Bastides
  • Function : Author
Adélaïde Chesnay
Audrey Therby
  • Function : Author
Elisabeth Chachaty
  • Function : Author
Bertrand Gachot
  • Function : Author

Abstract

The French National Reference Center for Invasive Mycoses and Antifungals leads an active and sustained nationwide surveillance program on probable and proven invasive fungal diseases (IFDs) to determine their epidemiology in France. Between 2012 and 2018, a total of 10,886 IFDs were recorded. The incidence increased slightly over time (2.16 to 2.36/10,000 hospitalization days, P = 0.0562) in relation with an increase of fungemia incidence (1.03 to 1.19/10,000, P = 0.0023), while that of other IFDs remained stable. The proportion of ≥65-year-old patients increased from 38.4% to 45.3% (P < 0.0001). Yeast fungemia (n = 5,444) was due mainly to Candida albicans (55.6%) with stable proportions of species over time. Echinocandins became the main drug prescribed (46.7% to 61.8%), but global mortality rate remained unchanged (36.3% at 1 month). Pneumocystis jirovecii pneumonia (n = 2,106) was diagnosed mostly in HIV-negative patients (80.7%) with a significantly higher mortality than in HIV-positive patients (21.9% versus 5.4% at 1 month, P < 0.0001). Invasive aspergillosis (n = 1,661) and mucormycosis (n = 314) were diagnosed mostly in hematology (>60% of the cases) with a global mortality rate of 42.5% and 59.3%, respectively, at 3 months and significant changes in diagnosis procedure over time. More concurrent infections were also diagnosed over time (from 5.4% to 9.4% for mold IFDs, P = 0.0115). In conclusion, we observed an aging of patients with IFD with a significant increase in incidence only for yeast fungemia, a trend toward more concurrent infections, which raises diagnostic and therapeutic issues. Overall, global survival associated with IFDs has not improved despite updated guidelines and new diagnostic tools. IMPORTANCE The epidemiology of invasive fungal diseases (IFDs) is hard to delineate given the difficulties in ascertaining the diagnosis that is often based on the confrontation of clinical and microbiological criteria. The present report underlines the interest of active surveillance involving mycologists and clinicians to describe the global incidence and that of the main IFDs. Globally, although the incidence of Pneumocystis pneumonia, invasive aspergillosis, and mucormycosis remained stable over the study period (2012 to 2018), that of yeast fungemia increased slightly. We also show here that IFDs seem to affect older people more frequently. The most worrisome observation is the lack of improvement in the global survival rate associated with IFDs despite the increasing use of more sensitive diagnostic tools, the availability of new antifungal drugs very active in clinical trials, and a still low/marginal rate of acquired in vitro resistance in France. Therefore, other tracks of improvement should be investigated actively.
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hal-03658122 , version 1 (04-05-2022)

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Stéphane Bretagne, Karine Sitbon, Marie Desnos-Ollivier, Dea Garcia-Hermoso, Valérie Letscher-Bru, et al.. Active Surveillance Program to Increase Awareness on Invasive Fungal Diseases: the French RESSIF Network (2012 to 2018). mBio, 2022, 13 (3), pp.e0092022. ⟨10.1128/mbio.00920-22⟩. ⟨hal-03658122⟩
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